Id http://purl.bioontology.org/ontology/MEDDRA/20000154
http://purl.bioontology.org/ontology/MEDDRA/20000154
Preferred Name

Demyelination (SMQ)

Definitions
Demyelination: loss of myelin with preservation of the axons or fiber tracts. Group of diseases of nervous system with damage and destruction of myelin sheaths surrounding nerve fibers. Axons may be damaged as well. Mechanism of myelin damage may be different in various diseases. Impairs conduction of signals in affected nerves. Causes impairment in sensation, movement, cognition, or other functions. Most common demyelinating disease is multiple sclerosis. Other examples include central pontine myelinolysis, progressive multifocal leukoencephalopathy, and subacute combined degeneration of spinal cord. Central demyelination occurs within central nervous system (e.g., multiple sclerosis). Peripheral demyelination affects peripheral nervous system (e.g., Guillain-Barre syndrome). Other causes: genetic, autoimmune reaction, immunological disorders, nutritional or metabolic disorder, toxins (including some used in therapy such as anti-mitotic agents and radiotherapy), unknown.
Type http://www.w3.org/2002/07/owl#Class
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