Link to this page
Medical Dictionary for Regulatory Activities Terminology (MedDRA)
Id | http://purl.bioontology.org/ontology/MEDDRA/20000154
http://purl.bioontology.org/ontology/MEDDRA/20000154
|
---|---|
Preferred Name | Demyelination (SMQ) |
Definitions |
Demyelination: loss of myelin with preservation of the axons or fiber tracts. Group of diseases of nervous system with damage and destruction of myelin sheaths surrounding nerve fibers. Axons may be damaged as well. Mechanism of myelin damage may be different in various diseases. Impairs conduction of signals in affected nerves. Causes impairment in sensation, movement, cognition, or other functions. Most common demyelinating disease is multiple sclerosis. Other examples include central pontine myelinolysis, progressive multifocal leukoencephalopathy, and subacute combined degeneration of spinal cord. Central demyelination occurs within central nervous system (e.g., multiple sclerosis). Peripheral demyelination affects peripheral nervous system (e.g., Guillain-Barre syndrome). Other causes: genetic, autoimmune reaction, immunological disorders, nutritional or metabolic disorder, toxins (including some used in therapy such as anti-mitotic agents and radiotherapy), unknown.
|
Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | Demyelination: loss of myelin with preservation of the axons or fiber tracts. Group of diseases of nervous system with damage and destruction of myelin sheaths surrounding nerve fibers. Axons may be damaged as well. Mechanism of myelin damage may be different in various diseases. Impairs conduction of signals in affected nerves. Causes impairment in sensation, movement, cognition, or other functions. Most common demyelinating disease is multiple sclerosis. Other examples include central pontine myelinolysis, progressive multifocal leukoencephalopathy, and subacute combined degeneration of spinal cord. Central demyelination occurs within central nervous system (e.g., multiple sclerosis). Peripheral demyelination affects peripheral nervous system (e.g., Guillain-Barre syndrome). Other causes: genetic, autoimmune reaction, immunological disorders, nutritional or metabolic disorder, toxins (including some used in therapy such as anti-mitotic agents and radiotherapy), unknown. |
---|---|
prefLabel | Demyelination (SMQ)
|
notation | 20000154
|
SMQ STATUS | A
|
SMQ LEVEL | 1
|
Semantic type UMLS property | |
type | |
Scope Statement | If searching for a de novo signal of demyelination, it is recommended to use the narrow and broad terms in this SMQ and also SMQ Peripheral neuropathy and SMQ Guillain-Barre syndrome. Broad terms for signs and symptoms of demyelinating diseases were excluded because they are in SMQ Peripheral neuropathy and SMQ Guillain-Barre syndrome. Some broad terms were also excluded as being too non-specific, related to advanced demyelination, or because of poor performance in SMQ testing. These excluded terms (see Tables 1 and 2 in the original CIOMS WG documentation) may be included in a search at the user's discretion.
|
tui | T185
|
cui | C2363989
|
Has member |
See more
See less
|
SMQ SOURCE | |
SMQ ALGO | N
|
Delete | Subject | Author | Type | Created |
---|---|---|---|---|
No notes to display |
- Problem retrieving properties:
Notes
Add NCBO Web Widgets to your site for MEDDRA
Widget type | Widget demonstration |
---|---|
|
Step 2: Follow the Instructions
For more help visit NCBO Widget Wiki |
|
Example 1 (start typing the class name to get its full URI)
Example 2 (get the ID for a class) Example 3 (get the preferred name for a class) Step 2: Follow the Instructions
For more help visit NCBO Widget Wiki |
|
Step 2: Follow the InstructionsCopy the code below and paste it to your HTML page <iframe frameborder="0" src="/widgets/visualization?ontology=MEDDRA&class=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMEDDRA%2F10001665&apikey=YOUR_API_KEY"></iframe> For more help visit NCBO Widget Wiki |