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Medical Dictionary for Regulatory Activities Terminology (MedDRA)
Acronym | MEDDRA |
Visibility | Public |
Description | MedDRA is an international medical terminology with an emphasis on use for data entry, retrieval, analysis, and display. It applies to all phases of drug development, excluding animal toxicology, and to the health effects and malfunction of devices. An appendix includes concept descriptions which describe how a medical concept is interpreted, used, and classified within the MedDRA terminology. It is not intended as a medical definition. The concept descriptions are intended to aid the consistent and accurate use of MedDRA in coding, retrieval, and analysis. |
Status | Production |
Format | UMLS |
Contact | MedDRA MSSO, mssohelp@meddra.org |
Categories | Health |
Groups | Cancer Biomedical Informatics Grid, Unified Medical Language System |
License Information | The MedDRA ontology is maintained and distributed by the MedDRA MSSO. This ontology is freely accessible on this site for academic and other non-commercial uses. Users anticipating any commercial use of MedDRA must contact the MSSO to obtain a license. |
Version | Released | Uploaded |
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MDR27_0 (Parsed, Indexed, Metrics, Annotator, Error Diff) | 11/04/2024 | 01/16/2025 |
2024AA (Archived) | 05/06/2024 | 08/28/2024 |
2023AB (Archived) | 11/06/2023 | 01/31/2024 |
2023AA (Archived) | 04/01/2023 | 08/07/2023 |
2022AB (Archived) | 11/07/2022 | 01/06/2023 |
2022AA (Archived) | 05/02/2022 | 06/10/2022 |
2021AB (Archived) | 11/01/2021 | 11/18/2021 |
2021AA (Archived) | 04/03/2021 | 05/20/2021 |
2020AB (Archived) | 11/02/2020 | 01/06/2021 |
2020AA (Archived) | 05/05/2020 | 09/24/2020 |
2019AB (Archived) | 11/04/2019 | 11/18/2019 |
2019AA (Archived) | 05/06/2019 | 08/27/2019 |
2018AB (Archived) | 11/05/2018 | 04/29/2019 |
2018AA (Archived) | 05/07/2018 | 07/06/2018 |
2017AB (Archived) | 11/06/2017 | 07/06/2018 |
2017AA (Archived) | 05/08/2017 | 04/06/2018 |
2016AB (Archived) | 02/06/2017 | 02/06/2017 |
2016AA (Archived) | 09/06/2016 | 09/06/2016 |
2015AB (Archived) | 07/20/2016 | 07/20/2016 |
2015AA (Archived) | 06/09/2015 | 06/09/2015 |
2014AB (Archived) | 01/29/2015 | 01/29/2015 |
2014AA (Archived) | 05/28/2014 | 05/28/2014 |
2013AB (Archived) | 02/18/2014 | 02/18/2014 |
2013AA (Archived) | 01/14/2014 | 01/14/2014 |
2013AA (Archived) | 05/08/2013 | 09/25/2013 |
more... |
- MedDRA French
- This is the French translation of the Medical Dictionary for Regulatory Activities (MedDRA).
- MedDRA German
- This is the German translation of the Medical Dictionary for Regulatory Activities (MedDRA).
Classes | 81,485 |
Individuals | 0 |
Properties | 13 |
Maximum depth | 7 |
Maximum number of children | 0 |
Average number of children | 0 |
Classes with a single child | 0 |
Classes with more than 25 children | 0 |
Classes with no definition | 81,255 |
Id | http://purl.bioontology.org/ontology/MEDDRA/20000154
http://purl.bioontology.org/ontology/MEDDRA/20000154
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Preferred Name | Demyelination (SMQ) |
Definitions |
Demyelination: loss of myelin with preservation of the axons or fiber tracts. Group of diseases of nervous system with damage and destruction of myelin sheaths surrounding nerve fibers. Axons may be damaged as well. Mechanism of myelin damage may be different in various diseases. Impairs conduction of signals in affected nerves. Causes impairment in sensation, movement, cognition, or other functions. Most common demyelinating disease is multiple sclerosis. Other examples include central pontine myelinolysis, progressive multifocal leukoencephalopathy, and subacute combined degeneration of spinal cord. Central demyelination occurs within central nervous system (e.g., multiple sclerosis). Peripheral demyelination affects peripheral nervous system (e.g., Guillain-Barre syndrome). Other causes: genetic, autoimmune reaction, immunological disorders, nutritional or metabolic disorder, toxins (including some used in therapy such as anti-mitotic agents and radiotherapy), unknown.
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | Demyelination: loss of myelin with preservation of the axons or fiber tracts. Group of diseases of nervous system with damage and destruction of myelin sheaths surrounding nerve fibers. Axons may be damaged as well. Mechanism of myelin damage may be different in various diseases. Impairs conduction of signals in affected nerves. Causes impairment in sensation, movement, cognition, or other functions. Most common demyelinating disease is multiple sclerosis. Other examples include central pontine myelinolysis, progressive multifocal leukoencephalopathy, and subacute combined degeneration of spinal cord. Central demyelination occurs within central nervous system (e.g., multiple sclerosis). Peripheral demyelination affects peripheral nervous system (e.g., Guillain-Barre syndrome). Other causes: genetic, autoimmune reaction, immunological disorders, nutritional or metabolic disorder, toxins (including some used in therapy such as anti-mitotic agents and radiotherapy), unknown. |
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prefLabel | Demyelination (SMQ)
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notation | 20000154
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SMQ STATUS | A
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SMQ LEVEL | 1
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Semantic type UMLS property | |
type | |
Scope Statement | If searching for a de novo signal of demyelination, it is recommended to use the narrow and broad terms in this SMQ and also SMQ Peripheral neuropathy and SMQ Guillain-Barre syndrome. Broad terms for signs and symptoms of demyelinating diseases were excluded because they are in SMQ Peripheral neuropathy and SMQ Guillain-Barre syndrome. Some broad terms were also excluded as being too non-specific, related to advanced demyelination, or because of poor performance in SMQ testing. These excluded terms (see Tables 1 and 2 in the original CIOMS WG documentation) may be included in a search at the user's discretion.
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tui | T185
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cui | C2363989
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Has member |
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SMQ SOURCE | |
SMQ ALGO | N
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Notes
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Widget type | Widget demonstration |
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Step 2: Follow the Instructions
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Example 1 (start typing the class name to get its full URI)
Example 2 (get the ID for a class) Example 3 (get the preferred name for a class) Step 2: Follow the Instructions
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Step 2: Follow the InstructionsCopy the code below and paste it to your HTML page <iframe frameborder="0" src="/widgets/visualization?ontology=MEDDRA&class=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMEDDRA%2F10001665&apikey=YOUR_API_KEY"></iframe> For more help visit NCBO Widget Wiki |