Medical Subject Headings

Last uploaded: January 16, 2025
Id http://purl.bioontology.org/ontology/MESH/D000071186
http://purl.bioontology.org/ontology/MESH/D000071186
Preferred Name

Beclin-1

Definitions
An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.
Synonyms
GT197 Protein
Coiled-coil Myosin-like Bcl2-interacting Protein
Beclin1
Beclin 1 Protein
Beclin 1
ATG-6 Protein
ATG 6 Protein
Coiled coil Myosin like Bcl2 interacting Protein
Beclin-1 Protein
ATG6 Protein
Type http://www.w3.org/2002/07/owl#Class
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