Medical Subject Headings

Last uploaded: January 16, 2025
Id http://purl.bioontology.org/ontology/MESH/D000073940
http://purl.bioontology.org/ontology/MESH/D000073940
Preferred Name

Transcription Factor 4

Definitions
A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
Synonyms
TCF-4 Transcription Factor
TCF 4 Transcription Factor
TCF-4 Protein
TCF4 Transcription Factor
Transcription Factor, TCF-4
Transcription Factor, TCF4
TCF 4 Protein
Type http://www.w3.org/2002/07/owl#Class
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