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Last uploaded: January 31, 2024

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Preferred Name	Cytochrome P-450 Enzyme System
Synonyms	Cytochrome P 450 Enzyme System P450 Enzymes
Definitions	A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
ID	http://purl.bioontology.org/ontology/MESH/D003577
altLabel	Cytochrome P 450 Enzyme System Cytochrome P 450 Dependent Monooxygenase Cytochrome P-450 Enzymes Cytochrome p450 Families Cytochrome P-450 Superfamily, Cytochrome P-450 Cytochrome P 450 Superfamily Cytochrome P-450-Dependent Monooxygenase Cytochrome P-450 Families Superfamily, Cytochrome P450 P-450 Enzymes, Cytochrome Superfamily, CYP450 Enzymes, P-450 Enzymes, P450 Cytochrome P-450 Monooxygenase Enzyme, Cytochrome P-450 P 450 Enzymes Cytochrome P 450 Cytochrome P450 Cytochrome P 450 Enzyme Monooxygenase, Cytochrome P-450 Cytochrome P-450 Superfamily Enzyme, P450 P-450 Enzyme, Cytochrome Cytochrome P 450 Monooxygenase P-450 Enzymes Monooxygenase, Cytochrome P-450-Dependent Enzymes, Cytochrome P-450 Cytochrome P450 Superfamily Cytochrome P 450 Oxygenase Enzyme, P-450 P-450 Enzyme P450 Enzyme CYP450 Superfamily Cytochrome P-450 Enzyme Cytochrome P-450 Oxygenase Cytochrome P 450 Families P 450 Enzyme CYP450 Family Cytochrome P 450 Enzymes P450 Enzymes
AN	general or unspecified; prefer specific cytochrome P-450's
AQL	AD AE AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui	C0056967 C0010762 C0111840
DC	1
definition	A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
DX	19730101
EC	antagonists & inhibitors:Cytochrome P-450 Enzyme Inhibitors
HN	73; CYTOCHROME P-450 OXYGENASE was NM 1977-96
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	9035-51-2 0
Machine permutation	73; CYTOCHROME P-450 OXYGENASE was indexed under CYTOCHROME P-450 & OXYGENASES 1977-96
Mapped from	http://purl.bioontology.org/ontology/MESH/C101653 http://purl.bioontology.org/ontology/MESH/C109362 http://purl.bioontology.org/ontology/MESH/C088251 http://purl.bioontology.org/ontology/MESH/C473194 http://purl.bioontology.org/ontology/MESH/C093818 http://purl.bioontology.org/ontology/MESH/C436961 http://purl.bioontology.org/ontology/MESH/C035796 http://purl.bioontology.org/ontology/MESH/C500774 http://purl.bioontology.org/ontology/MESH/C403885 http://purl.bioontology.org/ontology/MESH/C512110 http://purl.bioontology.org/ontology/MESH/C045620 http://purl.bioontology.org/ontology/MESH/C445019 http://purl.bioontology.org/ontology/MESH/C580848 http://purl.bioontology.org/ontology/MESH/C088751 http://purl.bioontology.org/ontology/MESH/C426839 http://purl.bioontology.org/ontology/MESH/C092555 http://purl.bioontology.org/ontology/MESH/C581568 http://purl.bioontology.org/ontology/MESH/C105438 http://purl.bioontology.org/ontology/MESH/C402671 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MDA	19990101
MMR	20200527
MN	D08.811.682.690.708.170 D08.244.453 D12.776.422.220.453
notation	D003577
prefLabel	Cytochrome P-450 Enzyme System
TERMUI	T000997454 T852910 T485421 T000997451 T000899537 T000899533 T010408 T010410 T000899532 T010407 T000899536 T000899534 T010409 T000997453 T000899535 T854676 T852909 T010411
TH	NLM (1997) NLM (1973) NLM (2015) UNK (19XX) NLM (2021) NLM (2003) NLM (2017)
tui	T116 T126
subClassOf	http://purl.bioontology.org/ontology/MESH/D003580 http://purl.bioontology.org/ontology/MESH/D006899

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/MSHFRE/D003577	MSHFRE	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/424446007	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D003577	MSHFRE	CUI
http://purl.bioontology.org/ontology/SCTSPA/424446007	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000170028	NDFRT	CUI
http://purl.bioontology.org/ontology/CSP/1418-4903	CRISP	CUI
http://purl.bioontology.org/ontology/MSHFRE/D003577	MSHFRE	CUI
http://purl.bioontology.org/ontology/MESH/D003577	GSSO	SAME_URI
http://www.phoc.org.cn/pmo/class/PMO_00019211	PMAPP-PMO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003577	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.776.422.220.453	RH-MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0004863	OMIT	LOOM
http://purl.obolibrary.org/obo/MESH_D003577	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.682.690.708.170	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.244.453	RH-MESH	LOOM