loading...| Preferred Name |
DNA Damage |
|
| Synonyms |
Stress, Genotoxic Injury, DNA |
|
| Definitions |
DNA DAMAGE in vivo. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D004249 |
|
| altLabel |
Stress, Genotoxic DNA Lesion DNA Injuries DNA Lesions DNA Injury Genotoxic Stress Injury, DNA |
|
| AN |
do not use /drug eff & /rad eff for DNA damage induced by drugs or radiation; do not confuse with DNA FRAGMENTATION: see note there |
|
| AQL |
DE ES GE IM PH RE |
|
| cui |
C1257899 C0012860 |
|
| DC |
1 |
|
| definition |
DNA DAMAGE in vivo. Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS. |
|
| DX |
19870101 |
|
| FX |
D009154 |
|
| HN |
87 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000941 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000187 |
|
| Inverse of RO |
http://purl.bioontology.org/ontology/MESH/D004260 http://purl.bioontology.org/ontology/MESH/D011740 http://purl.bioontology.org/ontology/MESH/D045643 |
|
| Machine permutation |
87 |
|
| MDA |
19860619 |
|
| MMR |
20230526 |
|
| MN |
G05.200 |
|
| notation |
D004249 |
|
| prefLabel |
DNA Damage |
|
| TERMUI |
T012899 T530921 T012898 T530920 T001134461 T012897 T001134462 |
|
| TH |
NLM (2004) NLM (1987) UNK (19XX) NLM (2024) |
|
| tui |
T049 |
|
| subClassOf |