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January 16, 2025
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| Id | http://purl.bioontology.org/ontology/MESH/D008148
http://purl.bioontology.org/ontology/MESH/D008148
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|---|---|
| Preferred Name | Lovastatin |
| Definitions |
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
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| Synonyms |
Lovastatin, 1 alpha Isomer
Monacolin K
Lovastatin, 1 alpha-Isomer
6-Methylcompactin
MK-803
Lovastatin, (1 alpha(S*))-Isomer
Mevacor
Mevinolin
MK 803
Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-
alpha-Isomer Lovastatin, 1
6 Methylcompactin
1 alpha-Isomer Lovastatin
MK803
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|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. |
|---|---|
| altLabel | Lovastatin, 1 alpha Isomer
Monacolin K
Lovastatin, 1 alpha-Isomer
6-Methylcompactin
MK-803
Lovastatin, (1 alpha(S*))-Isomer
Mevacor
Mevinolin
MK 803
Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-
alpha-Isomer Lovastatin, 1
6 Methylcompactin
1 alpha-Isomer Lovastatin
MK803
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| prefLabel | Lovastatin
|
| TH |
NLM (1999)
NLM (2012)
FDA SRS (2014)
UNK (19XX)
INN (19XX)
USAN (1987)
USP (19XX)
BAN (19XX)
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| notation | D008148
|
| RR |
79902-41-3 (1 alpha-isomer without R*/S* notation)
79952-44-6 ((1 alpha(S*))-isomer)
75330-75-5 (Lovastatin)
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| DX | 19880101
|
| Machine permutation | 88; MONACOLIN K was indexed under NAPHTHALENES 1981-98 & ANTIBIOTICS 1980
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| MN |
D04.615.638.400
D02.455.426.559.847.638.400
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| PA |
D019161
D000924
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| MMR | 20150623
|
| Mapped from |
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| AQL | AA AD AE AG AI AN BI BL CF CH CL CS EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UR
|
| HN | 88; for MONACOLIN K use LOVASTATIN (NM) 1980-98
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| subClassOf | |
| Semantic type UMLS property | |
| Inverse of RB |
79952-44-6
79902-41-3
0
9LHU78OQFD
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| LT | TRD
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| DC | 1
|
| MDA | 19870504
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| type | |
| tui |
T109
T121
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| cui |
C0733675
C0024027
C0887160
C0728780
C0887159
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| isa | |
| Inverse of AQ |
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| TERMUI |
T024294
T814218
T024293
T024291
T024290
T024292
T024289
T360285
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