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Last uploaded: January 31, 2024

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Preferred Name	Protein Kinase C
Synonyms	Phospholipid Sensitive Calcium Dependent Protein Kinase Phospholipid-Dependent Kinase, Calcium-Activated PKC Serine Threonine Kinase Calcium Phospholipid-Dependent Protein Kinase Protein Kinase M Calcium Phospholipid Dependent Protein Kinase Phospholipid-Sensitive Calcium-Dependent Protein Kinase Calcium Activated Phospholipid Dependent Kinase PKC Serine-Threonine Kinase Calcium-Activated Phospholipid-Dependent Kinase Serine-Threonine Kinase, PKC
Definitions	An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
ID	http://purl.bioontology.org/ontology/MESH/D011493
altLabel	Phospholipid Sensitive Calcium Dependent Protein Kinase Phospholipid-Dependent Kinase, Calcium-Activated PKC Serine Threonine Kinase Calcium Phospholipid-Dependent Protein Kinase Protein Kinase M Calcium Phospholipid Dependent Protein Kinase Phospholipid-Sensitive Calcium-Dependent Protein Kinase Calcium Activated Phospholipid Dependent Kinase PKC Serine-Threonine Kinase Calcium-Activated Phospholipid-Dependent Kinase Serine-Threonine Kinase, PKC
AQL	AD AE AI AN BI BL CF CH CL CS DE DF EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR
cui	C0033634 C0033638
DC	1
definition	An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
DX	19860101
HN	86; CALCIUM PHOSPHOLIPID-DEPENDENT PROTEIN KINASE was CALCIUM-PHOSPHOLIPID DEPENDENT PROTEIN KINASE 1986-93
Inverse of AQ	http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000172 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 http://purl.bioontology.org/ontology/MESH/Q000652 http://purl.bioontology.org/ontology/MESH/Q000528
Inverse of RB	EC 2.7.11.13 0
Machine permutation	86; CALCIUM PHOSPHOLIPID-DEPENDENT PROTEIN KINASE was CALCIUM-PHOSPHOLIPID DEPENDENT PROTEIN KINASE 1986-93
Mapped from	http://purl.bioontology.org/ontology/MESH/C000708935 http://purl.bioontology.org/ontology/MESH/C087857 http://purl.bioontology.org/ontology/MESH/C504730 http://purl.bioontology.org/ontology/MESH/C119190 http://purl.bioontology.org/ontology/MESH/C484814 http://purl.bioontology.org/ontology/MESH/C115197 http://purl.bioontology.org/ontology/MESH/C103744 http://purl.bioontology.org/ontology/MESH/C115015 http://purl.bioontology.org/ontology/MESH/C121046 http://purl.bioontology.org/ontology/MESH/C073885 http://purl.bioontology.org/ontology/MESH/C490702 http://purl.bioontology.org/ontology/MESH/C524695 http://purl.bioontology.org/ontology/MESH/C000634148 http://purl.bioontology.org/ontology/MESH/C097994 http://purl.bioontology.org/ontology/MESH/C097993 http://purl.bioontology.org/ontology/MESH/C072093 http://purl.bioontology.org/ontology/MESH/C576752 http://purl.bioontology.org/ontology/MESH/C061570 http://purl.bioontology.org/ontology/MESH/C511267 http://purl.bioontology.org/ontology/MESH/C576769 http://purl.bioontology.org/ontology/MESH/C081975 http://purl.bioontology.org/ontology/MESH/C488488 http://purl.bioontology.org/ontology/MESH/C000708940 http://purl.bioontology.org/ontology/MESH/C000720325 http://purl.bioontology.org/ontology/MESH/C089212 http://purl.bioontology.org/ontology/MESH/C579820 http://purl.bioontology.org/ontology/MESH/C087094 http://purl.bioontology.org/ontology/MESH/C104969 http://purl.bioontology.org/ontology/MESH/C532584 http://purl.bioontology.org/ontology/MESH/C088238 http://purl.bioontology.org/ontology/MESH/C027776
MDA	19850517
MMR	20210521
MN	D08.811.913.696.620.682.700.725 D12.776.476.563.725
notation	D011493
prefLabel	Protein Kinase C
TERMUI	T033940 T033942 T033941 T033939 T033944 T637820
TH	UNK (19XX) NLM (1986) NLM (2006)
tui	T116 T126
subClassOf	http://purl.bioontology.org/ontology/MESH/D017346

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/CSP/2312-2785	CRISP	CUI
http://purl.bioontology.org/ontology/MSHFRE/D011493	MSHFRE	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/416950008	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/MSHFRE/D011493	MSHFRE	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000168231	NDFRT	CUI
http://purl.bioontology.org/ontology/SCTSPA/416950008	SCTSPA	CUI
http://purl.bioontology.org/ontology/CSP/2312-2785	CRISP	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/416950008	SNOMEDCT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.913.696.620.682.700.725	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D011493	BERO	LOOM
http://purl.obolibrary.org/obo/OMIT_0012438	OMIT	LOOM
http://purl.obolibrary.org/obo/NCIT_C17017	BERO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17017	NCIT	LOOM
http://regenbase.org/ontology#RB_0000274	RB	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00020579	PMAPP-PMO	LOOM
http://purl.jp/bio/4/id/200906091571351007	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011493	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10243	OCHV	LOOM
http://doe-generated-ontology.com/OntoAD#C0033634	ONTOAD	LOOM
http://purl.obolibrary.org/obo/PR_000045382	PR	LOOM