loading...| Preferred Name |
Steroid 17-alpha-Hydroxylase |
|
| Synonyms |
17-alpha-Hydroxylase, Steroid |
|
| Definitions |
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D013254 |
|
| altLabel |
17-alpha-Hydroxylase, Steroid Aldolase, 17 alpha-Hydroxyprogesterone Aldolase, Hydroxyprogesterone Cytochrome P-450(17-alpha) Steroid 17 Monooxygenase Hydroxyprogesterone Aldolase Steroid 17 alpha Hydroxylase Cytochrome P-450(17 alpha) CYP17 17 alpha-Hydroxylase Cytochrome P-450 P450(c17) 17,20 Desmolase 17,20-Desmolase Steroid 17 Hydroxylase 17,20 Lyase 17 alpha Hydroxylase Cytochrome P 450 17 alpha-Hydroxylase, Steroid alpha-Hydroxyprogesterone Aldolase, 17 Steroid 17-Hydroxylase 17 alpha-Hydroxyprogesterone Aldolase 17,20-Lyase Steroid 17-Monooxygenase Steroid 17 alpha-Monooxygenase Steroid-17-Hydroxylase 17 alpha-Monooxygenase, Steroid Cytochrome P450(17 alpha) 17 alpha Hydroxylase 17-Monooxygenase, Steroid Steroid 17 alpha-Hydroxylase 17 alpha Hydroxyprogesterone Aldolase 17 alpha-Hydroxylase Steroid 17 alpha Monooxygenase 17-Hydroxylase, Steroid Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating) alpha-Monooxygenase, Steroid 17 |
|
| AQL |
AD AE AI AN BI BL CF CH CL CS DE EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR |
|
| cui |
C0044970 C0038302 |
|
| DC |
1 |
|
| definition |
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation. |
|
| DX |
19910101 |
|
| EC |
deficiency:Adrenal Hyperplasia, Congenital |
|
| FX |
D000312 |
|
| HN |
2003 (1978) |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
| Inverse of RB |
EC 1.14.14.19 0 |
|
| Inverse of RO | ||
| Machine permutation |
2003; see STEROID 17 ALPHA-MONOOXYGENASE 1997-2002, see STEROID 17-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1990; for STEROID-17-HYDROXYLASE see STEROID HYDROXYLASES 1978-1989; for 17,20-LYASE see 17 ALPHA-HYDROXYPROGESTERONE ALDOLASE 1996-1997 |
|
| Mapped from |
http://purl.bioontology.org/ontology/MESH/C000607915 http://purl.bioontology.org/ontology/MESH/C582555 http://purl.bioontology.org/ontology/MESH/C501892 http://purl.bioontology.org/ontology/MESH/C022433 |
|
| MDA |
19770415 |
|
| MMR |
20160601 |
|
| MN |
D08.811.682.690.708.170.444.500 D08.811.682.690.708.170.915.748 D08.244.453.487.500 D08.244.453.915.748 D12.776.422.220.453.487.500 D12.776.422.220.453.915.748 |
|
| notation |
D013254 |
|
| prefLabel |
Steroid 17-alpha-Hydroxylase |
|
| RR |
9029-67-8 (CAS RN) 62213-24-5 (CAS RN) |
|
| TERMUI |
T494562 T038954 T108454 T038957 T038956 T057864 T038953 T038961 T038959 T038955 T038952 T038950 T038962 T038958 T038951 T057865 T038960 |
|
| TH |
NLM (1997) NLM (1990) NLM (1978) UNK (19XX) NLM (2003) NLM (1998) |
|
| tui |
T116 T126 |
|
| subClassOf |