loading...| Preferred Name |
Neurofibrillary Tangles |
|
| Synonyms |
Tangles, Neurofibrillary |
|
| Definitions |
Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease. |
|
| ID |
http://purl.bioontology.org/ontology/MESH/D016874 |
|
| altLabel |
Tangles, Neurofibrillary Neurofibrillary Tangle Tangle, Neurofibrillary |
|
| AQL |
CH CL DE EN GE IM ME MI PA PH PS RE TR UL VI |
|
| cui |
C0085400 |
|
| DC |
1 |
|
| definition |
Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease. |
|
| DX |
19920101 |
|
| FX |
D016900 D009454 D055956 D024801 |
|
| HN |
92 |
|
| Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000469 http://purl.bioontology.org/ontology/MESH/Q000821 http://purl.bioontology.org/ontology/MESH/Q000473 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000382 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000201 |
|
| Inverse of RO |
http://purl.bioontology.org/ontology/MESH/D055956 http://purl.bioontology.org/ontology/MESH/D009454 |
|
| Machine permutation |
92 |
|
| MDA |
19910502 |
|
| MMR |
20140613 |
|
| MN |
A11.671.573.520 A08.675.609.520 A11.284.430.214.190.750.640.520 |
|
| notation |
D016874 |
|
| prefLabel |
Neurofibrillary Tangles |
|
| TERMUI |
T050513 |
|
| TH |
NLM (1992) |
|
| tui |
T049 |
|
| subClassOf |