Preferred Name |
Codon, Nonsense |
|
Synonyms |
Mutations, Amber Nonsense |
|
Definitions |
A mutation that converts a sense codon (CODON) into a stop codon (CODON, TERMINATOR) or an unassigned codon and leads to the formation of truncated proteins. |
|
ID |
http://purl.bioontology.org/ontology/MESH/D018389 |
|
altLabel |
Mutations, Amber Nonsense Nonsense Mutation, Amber Unassigned Codons Nonsense Mutation Mutations, Ochre Nonsense Nonsense Codon, Amber Stop Codon, Premature Codons, Premature Termination Opal Nonsense Mutations Nonsense Codons, Ochre Nonsense Codons, Opal Nonsense Mutations Nonsense Codon, Ochre Codons, Amber Nonsense Nonsense Mutation, Ochre Codon, Premature Stop Termination Codons, Premature Mutation, Amber Nonsense Nonsense Codon Codons, Unassigned Codon, Opal Nonsense Nonsense Codon, Opal Opal Nonsense Codon Nonsense Codons, Amber Unassigned Codon Premature Stop Codons Codons, Opal Nonsense Opal Nonsense Codons Mutation, Nonsense Amber Nonsense Codon Codon, Amber Nonsense Nonsense Mutations, Ochre Amber Nonsense Mutations Codon, Termination, Premature Stop Codons, Premature Ochre Nonsense Mutations Amber Nonsense Codons Premature Termination Codons Premature Termination Codon Nonsense Mutations, Opal Ochre Nonsense Codon Codons, Nonsense Ochre Nonsense Codons Codon, Ochre Nonsense Mutation, Ochre Nonsense Mutation, Opal Nonsense Codons, Ochre Nonsense Codon, Premature Termination Termination Codon, Premature Ochre Nonsense Mutation Premature Stop Codon Nonsense Mutations, Amber Nonsense Mutation, Opal Codons, Premature Stop Mutations, Nonsense Opal Nonsense Mutation Codon, Unassigned Mutations, Opal Nonsense Amber Nonsense Mutation Nonsense Codons |
|
AN |
for amber or ochre suppressor mutations use SUPPRESSION, GENETIC |
|
AQL |
AD AE AG AI AN BI BL CF CH CL CS DE EC GE HI IM IP ME PD PH PK PO RE SD ST TO TU UL UR |
|
cui |
C0917893 C1956155 C1956152 C1956156 C1956151 C1956154 C0544885 C0242612 C1956153 |
|
DC |
1 |
|
definition |
A mutation that converts a sense codon (CODON) into a stop codon (CODON, TERMINATOR) or an unassigned codon and leads to the formation of truncated proteins. An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon. A codon that is not assigned to an amino acid and is not a stop codon (CODON, TERMINATOR). Although they may lead to premature termination of translation, unassigned codons do not bind translation release factors (PEPTIDE TERMINATION FACTORS), as do stop codons. |
|
DX |
19950101 |
|
HN |
95 |
|
Inverse of AQ |
http://purl.bioontology.org/ontology/MESH/Q000097 http://purl.bioontology.org/ontology/MESH/Q000096 http://purl.bioontology.org/ontology/MESH/Q000627 http://purl.bioontology.org/ontology/MESH/Q000648 http://purl.bioontology.org/ontology/MESH/Q000493 http://purl.bioontology.org/ontology/MESH/Q000494 http://purl.bioontology.org/ontology/MESH/Q000276 http://purl.bioontology.org/ontology/MESH/Q000138 http://purl.bioontology.org/ontology/MESH/Q000134 http://purl.bioontology.org/ontology/MESH/Q000266 http://purl.bioontology.org/ontology/MESH/Q000378 http://purl.bioontology.org/ontology/MESH/Q000008 http://purl.bioontology.org/ontology/MESH/Q000009 http://purl.bioontology.org/ontology/MESH/Q000032 http://purl.bioontology.org/ontology/MESH/Q000037 http://purl.bioontology.org/ontology/MESH/Q000191 http://purl.bioontology.org/ontology/MESH/Q000302 http://purl.bioontology.org/ontology/MESH/Q000145 http://purl.bioontology.org/ontology/MESH/Q000592 http://purl.bioontology.org/ontology/MESH/Q000737 http://purl.bioontology.org/ontology/MESH/Q000819 http://purl.bioontology.org/ontology/MESH/Q000502 http://purl.bioontology.org/ontology/MESH/Q000506 http://purl.bioontology.org/ontology/MESH/Q000187 http://purl.bioontology.org/ontology/MESH/Q000235 http://purl.bioontology.org/ontology/MESH/Q000633 http://purl.bioontology.org/ontology/MESH/Q000600 |
|
Inverse of RB |
0 |
|
Machine permutation |
95 |
|
MDA |
19940603 |
|
MMR |
20130709 |
|
MN |
D13.444.735.544.355.250.235 G05.365.590.195 G05.360.335.355.250.235 |
|
notation |
D018389 |
|
prefLabel |
Codon, Nonsense |
|
TERMUI |
T686248 T054831 T414292 T412076 T414290 T686201 T686203 T054832 T412075 T054830 T686247 T686204 T412074 T414291 T686202 T686200 |
|
TH |
NLM (1995) NLM (2008) NLM (2001) |
|
tui |
T049 T086 T045 |
|
subClassOf |