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Last uploaded:
January 16, 2025
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| Id | http://purl.bioontology.org/ontology/MESH/D056811
http://purl.bioontology.org/ontology/MESH/D056811
|
|---|---|
| Preferred Name | Unfolded Protein Response |
| Definitions |
A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.
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| Synonyms |
Response, Unfolded Protein
Protein Response, Unfolded
Protein Responses, Unfolded
Responses, Unfolded Protein
Unfolded Protein Responses
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS. |
|---|---|
| altLabel |
Response, Unfolded Protein
Protein Response, Unfolded
Protein Responses, Unfolded
Responses, Unfolded Protein
Unfolded Protein Responses
|
| prefLabel | Unfolded Protein Response
|
| TH | NLM (2010)
|
| notation | D056811
|
| DX | 20100101
|
| Machine permutation | 2010
|
| MN |
G02.111.660.871.790.600.962
G03.734.871.790.600.850
G02.111.691.600.850
G04.434.500
G05.308.670.600.850
|
| FX |
D060746
D059865
|
| MMR | 20220712
|
| AQL | DE GE IM PH RE
|
| HN | 2010
|
| subClassOf | |
| Semantic type UMLS property | |
| DC | 1
|
| MDA | 20090706
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| Inverse of RO | |
| type | |
| tui | T043
|
| cui | C1155342
|
| Inverse of AQ | |
| TERMUI | T734690
|
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