loading...| Preferred Name |
Zalcitabine [Chemical/Ingredient] |
|
| Synonyms |
Dideoxycytidine Zalcitabine |
|
| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000006107 |
|
| altLabel |
Dideoxycytidine 2',3'-Dideoxycytidine Cytidine, 2',3'-dideoxy- ddC (Antiviral) Zalcitabine |
|
| cui |
C0012132 |
|
| Ingredient of | ||
| MESH DEFINITION |
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy. |
|
| MESH DUI |
D016047 |
|
| MeSH name |
Zalcitabine |
|
| MESH UI |
M0024532 |
|
| NDFRT kind |
INGREDIENT_KIND |
|
| notation |
N0000006107 |
|
| NUI |
N0000006107 |
|
| prefLabel |
Zalcitabine [Chemical/Ingredient] |
|
| tui |
T114 T121 |
|
| subClassOf |