loading...| Preferred Name |
Cisplatin [Chemical/Ingredient] |
|
| Synonyms |
Platinum Diamminodichloride |
|
| ID |
http://purl.bioontology.org/ontology/NDFRT/N0000007062 |
|
| altLabel |
Platinum Diamminodichloride cis-Diamminedichloroplatinum(II) cis-Dichlorodiammineplatinum(II) cis-Diamminedichloroplatinum cis-Platinum Cisplatin Platinum, diamminedichloro-, (SP-4-2)- Dichlorodiammineplatinum |
|
| cui |
C0008838 |
|
| Ingredient of |
http://purl.bioontology.org/ontology/NDFRT/N0000146476 http://purl.bioontology.org/ontology/NDFRT/N0000151873 http://purl.bioontology.org/ontology/NDFRT/N0000164789 |
|
| MESH DEFINITION |
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle. |
|
| MESH DUI |
D002945 |
|
| MeSH name |
Cisplatin |
|
| MESH UI |
M0004505 |
|
| NDFRT kind |
INGREDIENT_KIND |
|
| notation |
N0000007062 |
|
| NUI |
N0000007062 |
|
| prefLabel |
Cisplatin [Chemical/Ingredient] |
|
| tui |
T197 T121 |
|
| subClassOf |