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National Drug File - Reference Terminology
Last uploaded:
July 6, 2018
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| Id | http://purl.bioontology.org/ontology/NDFRT/N0000168736
http://purl.bioontology.org/ontology/NDFRT/N0000168736
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|---|---|
| Preferred Name | Integrins [Chemical/Ingredient] |
| Synonyms |
Integrins
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| altLabel | Integrins
|
|---|---|
| prefLabel | Integrins [Chemical/Ingredient]
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| notation | N0000168736
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| MESH DEFINITION | A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
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| MESH UI | M0024497
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| subClassOf | |
| Semantic type UMLS property | |
| MeSH name | Integrins
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| NDFRT kind | INGREDIENT_KIND
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| type | |
| tui |
T116
T129
T192
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| NUI | N0000168736
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| cui | C0021701
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| MESH DUI | D016023
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