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Physician Data Query
Id | http://purl.bioontology.org/ontology/PDQ/CDR0000747732
http://purl.bioontology.org/ontology/PDQ/CDR0000747732
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Preferred Name | chlorhexidine gluconate |
Definitions |
The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47974" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47974" NCI Thesaurus)
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Synonyms |
Peridex
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47974" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47974" NCI Thesaurus) |
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altLabel |
Peridex
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prefLabel |
chlorhexidine gluconate
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CAS Registry |
18472-51-0
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notation |
CDR0000747732
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ORIG STY |
Drug/agent
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Date last modified |
2015-10-06
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Semantic type UMLS property | |
NCI ID |
C47974
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type | |
LT |
TRD
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tui |
T109
T121
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DATE FIRST PUBLISHED |
2013-03-14
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cui |
C0728727
C0055361
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