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Physician Data Query
| Acronym | PDQ |
| Visibility | Public |
| Description | Physician Data Query (PDQ) Terminology is part of NCI's comprehensive cancer information database, which contains expert summaries on a wide range of cancer topics, a listing of some 30,000 cancer clinical trials from around the world, a directory of genetics services professionals, the NCI Dictionary of Cancer Terms, and the NCI Drug Dictionary. |
| Status | Production |
| Format | UMLS |
| Contact | Volker Englisch, volker@mail.nih.gov |
| Categories | Health |
| Groups | Unified Medical Language System |
| License Information | This ontology is made available via the UMLS. Users of all UMLS ontologies must abide by the terms of the UMLS license. |
| Version | Released | Uploaded | Downloads |
|---|---|---|---|
| PDQ_2018_10_27 (Parsed, Indexed, Metrics, Annotator) | 05/06/2019 | 08/27/2019 | RDF/TTL | CSV | Diff |
| 2018AB (Archived) | 11/05/2018 | 04/29/2019 | RDF/TTL | Diff |
| 2018AA (Archived) | 05/07/2018 | 07/06/2018 | RDF/TTL | Diff |
| 2017AB (Archived) | 11/06/2017 | 07/06/2018 | RDF/TTL | Diff |
| 2017AA (Archived) | 05/08/2017 | 04/06/2018 | RDF/TTL | Diff |
| 2016AB (Archived) | 02/06/2017 | 02/06/2017 | RDF/TTL | Diff |
| 2016AA (Archived) | 09/06/2016 | 09/06/2016 | RDF/TTL | Diff |
| 2015AB (Archived) | 07/20/2016 | 07/20/2016 | RDF/TTL | Diff |
| 2015AA (Archived) | 06/09/2015 | 06/09/2015 | RDF/TTL | Diff |
| 2014AB (Archived) | 01/29/2015 | 01/29/2015 | RDF/TTL | Diff |
| 2014AA (Archived) | 05/28/2014 | 05/28/2014 | RDF/TTL | Diff |
| 2013AB (Archived) | 02/18/2014 | 02/18/2014 | RDF/TTL | Diff |
| 2013AA (Archived) | 01/14/2014 | 01/14/2014 | RDF/TTL | Diff |
| 2013AA (Archived) | 05/08/2013 | 09/25/2013 | RDF/TTL | Diff |
| 2010_04_09 (Archived) | 04/09/2010 | 11/18/2010 | RDF/TTL |
| 2007_02 (Archived) | 02/01/2007 | 07/31/2009 | RDF/TTL |
| more... | |||
No views of PDQ available
| Id | http://purl.bioontology.org/ontology/PDQ/CDR0000780147
http://purl.bioontology.org/ontology/PDQ/CDR0000780147
|
|---|---|
| Preferred Name | ocrelizumab |
| Definitions |
A Fc-modified, humanized monoclonal antibody directed against the B-cell CD20 cell surface antigen, with immunosuppressive activity. Ocrelizumab binds to CD20 on the surfaces of B-cells, triggering complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) of B-cells overexpressing CD20. The CD20 antigen, a non-glycosylated cell surface phosphoprotein that acts as a calcium ion channel, is found on over 90% of B-cells, B-cell lymphomas, and other lymphoid tumor cells of B-cell origin; it plays an important role in B-cell functioning. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66250" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66250" NCI Thesaurus)
|
| Synonyms |
RO4964913
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A Fc-modified, humanized monoclonal antibody directed against the B-cell CD20 cell surface antigen, with immunosuppressive activity. Ocrelizumab binds to CD20 on the surfaces of B-cells, triggering complement-dependent cell lysis (CDCL) and antibody-dependent cell-mediated cytotoxicity (ADCC) of B-cells overexpressing CD20. The CD20 antigen, a non-glycosylated cell surface phosphoprotein that acts as a calcium ion channel, is found on over 90% of B-cells, B-cell lymphomas, and other lymphoid tumor cells of B-cell origin; it plays an important role in B-cell functioning. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66250" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C66250" NCI Thesaurus) |
|---|---|
| altLabel | RO4964913
|
| prefLabel | ocrelizumab
|
| CAS Registry | 637334-45-3
|
| notation | CDR0000780147
|
| ORIG STY | Drug/agent
|
| Date last modified | 2016-04-08
|
| Semantic type UMLS property | |
| NCI ID | C66250
|
| type | |
| tui |
T116
T129
T121
|
| DATE FIRST PUBLISHED | 2016-04-11
|
| cui |
C1882138
C4287714
|
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