SNOMED CT

Last uploaded: January 16, 2025
Id http://purl.bioontology.org/ontology/SNOMEDCT/1260467009
http://purl.bioontology.org/ontology/SNOMEDCT/1260467009
Preferred Name

Large congenital pigmented melanocytic nevus of skin

Definitions
A large or giant congenital melanocytic nevus (LCMN or GCMN) is a pigmented skin lesion of more than 20 cm - or 40 cm- respectively, projected adult diameter, composed of melanocytes and presenting with an elevated risk of malignant transformation. An LCMN is a darkly colored, circumscribed area of the skin sometimes covered with dense hair or proliferative nodules, and/or accompanied by multiple small satellite nevi that develop at birth or during early childhood (tardive satellites). Patients with LCMN also present an elevated risk of malignant pediatric melanoma, particularly intracranial, and other neuroectodermal tumors of varying severity. LCMN is a neurocristopathy (a disorder of the development of the embryonic neural crest) but its etiology is unknown. Familial cases have been observed, but the vast majority of LCMN cases are sporadic. A large or giant congenital melanocytic naevus (LCMN or GCMN) is a pigmented skin lesion of more than 20 cm - or 40 cm- respectively, projected adult diameter, composed of melanocytes and presenting with an elevated risk of malignant transformation. An LCMN is a darkly coloured, circumscribed area of the skin sometimes covered with dense hair or proliferative nodules, and/or accompanied by multiple small satellite naevi that develop at birth or during early childhood (tardive satellites). Patients with LCMN also present an elevated risk of malignant paediatric melanoma, particularly intracranial, and other neuroectodermal tumours of varying severity. LCMN is a neurocristopathy (a disorder of the development of the embryonic neural crest) but its aetiology is unknown. Familial cases have been observed, but the vast majority of LCMN cases are sporadic.
Synonyms
LCMN - large congenital melanocytic nevus
Large congenital pigmented melanocytic naevus of skin
LCMN - large congenital melanocytic naevus
Giant congenital melanocytic naevus
Large congenital pigmented melanocytic nevus of skin (disorder)
Giant congenital melanocytic nevus
GCMN - giant congenital melanocytic naevus
GCMN - giant congenital melanocytic nevus
Type http://www.w3.org/2002/07/owl#Class
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