loading...| Preferred Name |
Large congenital pigmented melanocytic nevus of skin |
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| Synonyms |
LCMN - large congenital melanocytic nevus |
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| Definitions |
A large or giant congenital melanocytic nevus (LCMN or GCMN) is a pigmented skin lesion of more than 20 cm - or 40 cm- respectively, projected adult diameter, composed of melanocytes and presenting with an elevated risk of malignant transformation. An LCMN is a darkly colored, circumscribed area of the skin sometimes covered with dense hair or proliferative nodules, and/or accompanied by multiple small satellite nevi that develop at birth or during early childhood (tardive satellites). Patients with LCMN also present an elevated risk of malignant pediatric melanoma, particularly intracranial, and other neuroectodermal tumors of varying severity. LCMN is a neurocristopathy (a disorder of the development of the embryonic neural crest) but its etiology is unknown. Familial cases have been observed, but the vast majority of LCMN cases are sporadic. |
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| ID |
http://purl.bioontology.org/ontology/SNOMEDCT/1260467009 |
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| Active |
1 |
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| altLabel |
LCMN - large congenital melanocytic nevus Large congenital pigmented melanocytic naevus of skin LCMN - large congenital melanocytic naevus Giant congenital melanocytic naevus Large congenital pigmented melanocytic nevus of skin (disorder) Giant congenital melanocytic nevus GCMN - giant congenital melanocytic naevus GCMN - giant congenital melanocytic nevus |
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| CASE SIGNIFICANCE ID |
900000000000448009 900000000000017005 |
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| CTV3ID |
XVK2j |
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| cui |
C1842036 |
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| definition |
A large or giant congenital melanocytic nevus (LCMN or GCMN) is a pigmented skin lesion of more than 20 cm - or 40 cm- respectively, projected adult diameter, composed of melanocytes and presenting with an elevated risk of malignant transformation. An LCMN is a darkly colored, circumscribed area of the skin sometimes covered with dense hair or proliferative nodules, and/or accompanied by multiple small satellite nevi that develop at birth or during early childhood (tardive satellites). Patients with LCMN also present an elevated risk of malignant pediatric melanoma, particularly intracranial, and other neuroectodermal tumors of varying severity. LCMN is a neurocristopathy (a disorder of the development of the embryonic neural crest) but its etiology is unknown. Familial cases have been observed, but the vast majority of LCMN cases are sporadic. A large or giant congenital melanocytic naevus (LCMN or GCMN) is a pigmented skin lesion of more than 20 cm - or 40 cm- respectively, projected adult diameter, composed of melanocytes and presenting with an elevated risk of malignant transformation. An LCMN is a darkly coloured, circumscribed area of the skin sometimes covered with dense hair or proliferative nodules, and/or accompanied by multiple small satellite naevi that develop at birth or during early childhood (tardive satellites). Patients with LCMN also present an elevated risk of malignant paediatric melanoma, particularly intracranial, and other neuroectodermal tumours of varying severity. LCMN is a neurocristopathy (a disorder of the development of the embryonic neural crest) but its aetiology is unknown. Familial cases have been observed, but the vast majority of LCMN cases are sporadic. |
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| DEFINITION STATUS ID |
900000000000074008 |
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| Effective time |
20230131 |
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| Has associated morphology | ||
| Has finding site | ||
| notation |
1260467009 |
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| Occurs in | ||
| prefLabel |
Large congenital pigmented melanocytic nevus of skin |
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| Subset member |
447562003~MAPRULE~TRUE 447562003~MAPTARGET~D22.9 6011000124106~MAPGROUP~1 900000000000497000~MAPTARGET~XVK2j 900000000000508004~ACCEPTABILITYID~900000000000549004 447562003~MAPGROUP~1 447562003~CORRELATIONID~447561005 6011000124106~MAPCATEGORYID~447637006 900000000000509007~ACCEPTABILITYID~900000000000548007 900000000000508004~ACCEPTABILITYID~900000000000548007 6011000124106~MAPTARGET~D22.9 447562003~MAPPRIORITY~1 447562003~MAPCATEGORYID~447637006 447562003~MAPADVICE~ALWAYS D22.9 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE 6011000124106~MAPPRIORITY~1 6011000124106~CORRELATIONID~447561005 6011000124106~MAPRULE~TRUE 900000000000509007~ACCEPTABILITYID~900000000000549004 6011000124106~MAPADVICE~ALWAYS D22.9 |
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| tui |
T191 |
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| Type ID |
900000000000003001 900000000000013009 |
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| subClassOf |