loading...| Preferred Name |
Insulinoma |
|
| Synonyms |
Insulinoma (disorder) Beta cell adenoma |
|
| Definitions |
A form of functioning pancreatic neuroendocrine tumour characterised most commonly by a solitary, small pancreatic lesion that causes hyperinsulinaemic hypoglycaemia. Insulinoma can present at any age but the median age of diagnosis is in the fifth decade of life. Insulinoma is malignant in only 7-10% of cases and the most common sites of metastasis are the liver and lymph nodes. The aetiology is unknown in most sporadic cases but somatic YY1 (14q32.2) variants are associated with insulinoma in some cases. Insulinoma originates in the islet beta cells that are equally distributed throughout the pancreas. When functioning, the tumour manifests with hypersecretion of insulin and consequently causes hypoglycaemia. With the exception of insulinoma in MEN1, insulinoma is not hereditary. |
|
| ID |
http://purl.bioontology.org/ontology/SNOMEDCT/302822000 |
|
| Active |
1 |
|
| altLabel |
Insulinoma (disorder) Beta cell adenoma |
|
| CASE SIGNIFICANCE ID |
900000000000448009 |
|
| CTV3ID |
Xa98M |
|
| cui |
C0021670 |
|
| definition |
A form of functioning pancreatic neuroendocrine tumour characterised most commonly by a solitary, small pancreatic lesion that causes hyperinsulinaemic hypoglycaemia. Insulinoma can present at any age but the median age of diagnosis is in the fifth decade of life. Insulinoma is malignant in only 7-10% of cases and the most common sites of metastasis are the liver and lymph nodes. The aetiology is unknown in most sporadic cases but somatic YY1 (14q32.2) variants are associated with insulinoma in some cases. Insulinoma originates in the islet beta cells that are equally distributed throughout the pancreas. When functioning, the tumour manifests with hypersecretion of insulin and consequently causes hypoglycaemia. With the exception of insulinoma in MEN1, insulinoma is not hereditary. A form of functioning pancreatic neuroendocrine tumor characterized most commonly by a solitary, small pancreatic lesion that causes hyperinsulinemic hypoglycemia. Insulinoma can present at any age but the median age of diagnosis is in the fifth decade of life. Insulinoma is malignant in only 7-10% of cases and the most common sites of metastasis are the liver and lymph nodes. The etiology is unknown in most sporadic cases but somatic YY1 (14q32.2) variants are associated with insulinoma in some cases. Insulinoma originates in the islet beta cells that are equally distributed throughout the pancreas. When functioning, the tumor manifests with hypersecretion of insulin and consequently causes hypoglycemia. With the exception of insulinoma in MEN1, insulinoma is not hereditary. |
|
| DEFINITION STATUS ID |
900000000000074008 |
|
| Effective time |
20230228 |
|
| Has associated morphology | ||
| Has finding site | ||
| INACTIVATION INDICATOR |
900000000000495008 900000000000484002 |
|
| notation |
302822000 |
|
| prefLabel |
Insulinoma |
|
| Subset member |
447562003~MAPRULE~TRUE 6011000124106~MAPTARGET~D37.8 900000000000523009~TARGETCOMPONENT~713189001 900000000000489007~VALUEID~900000000000484002 6011000124106~MAPGROUP~1 6011000124106~MAPADVICE~IF MALIGNANT INSULINOMA CHOOSE C25.4 | CONSIDER ADDITIONAL CODE TO IDENTIFY SPECIFIC CONDITION OR DISEASE | MAP OF SOURCE CONCEPT IS CONTEXT DEPENDENT 447562003~MAPADVICE~MAP SOURCE CONCEPT CANNOT BE CLASSIFIED WITH AVAILABLE DATA 447562003~MAPTARGET~D13.7 6011000124106~MAPTARGET~C25.4 900000000000490003~VALUEID~900000000000495008 900000000000508004~ACCEPTABILITYID~900000000000549004 447562003~MAPGROUP~1 447562003~CORRELATIONID~447561005 6011000124106~MAPCATEGORYID~447637006 447562003~MAPADVICE~ALWAYS D37.7 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE 900000000000509007~ACCEPTABILITYID~900000000000548007 6011000124106~MAPADVICE~ALWAYS D37.8 900000000000508004~ACCEPTABILITYID~900000000000548007 447562003~MAPTARGET~ 6011000124106~MAPRULE~IFA 713189001 | Malignant insulinoma (disorder) | 447562003~MAPPRIORITY~1 447562003~MAPCATEGORYID~447637006 6011000124106~MAPRULE~OTHERWISE TRUE 447562003~MAPTARGET~D37.7 6011000124106~MAPCATEGORYID~447639009 900000000000497000~MAPTARGET~Xa98M 447562003~MAPADVICE~ALWAYS D13.7 | POSSIBLE REQUIREMENT FOR MORPHOLOGY CODE 900000000000523009~TARGETCOMPONENT~788390005 6011000124106~MAPPRIORITY~1 6011000124106~CORRELATIONID~447561005 6011000124106~MAPRULE~TRUE 900000000000509007~ACCEPTABILITYID~900000000000549004 6011000124106~MAPPRIORITY~2 447562003~MAPCATEGORYID~447638001 |
|
| tui |
T191 |
|
| Type ID |
900000000000003001 900000000000013009 |
|
| subClassOf |