Physician Data Query

Last uploaded: August 27, 2019
Id http://purl.bioontology.org/ontology/PDQ/CDR0000037945
http://purl.bioontology.org/ontology/PDQ/CDR0000037945
Preferred Name

recombinant 70-kD heat-shock protein

Definitions
A recombinant peptide that is chemically identical to or similar to the endogenous 70-kD heat shock protein (HSP70). HSP70 is a molecular chaperone that prevents physiologic stress-induced cell death by inhibiting both caspase-dependent and caspase-independent apoptosis. Because this peptide is often overexpressed in tumor cells, autologous vaccination with HSP70 derived from tumor cells may stimulate the host immune system to mount a tumoricidal cytotoxic T lymphocyte (CTL) response. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28696" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28696" NCI Thesaurus)
Synonyms
70-kD Heat-Shock Protein
Heat Shock Protein 70
HSP70
Type http://www.w3.org/2002/07/owl#Class
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