Physician Data Query

Last uploaded: August 27, 2019
Id http://purl.bioontology.org/ontology/PDQ/CDR0000698431
http://purl.bioontology.org/ontology/PDQ/CDR0000698431
Preferred Name

estrogen receptor agonist GTx-758

Definitions
An orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition of LH secretion prevents the synthesis of androgens, including testosterone, by the testes. This may result in suppressed total serum testosterone to the levels observed in castration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C96432" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C96432" NCI Thesaurus)
Synonyms
Capesaris
GTx-758
Type http://www.w3.org/2002/07/owl#Class
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