estrogen receptor agonist GTx-758

Capesaris

An orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition of LH secretion prevents the synthesis of androgens, including testosterone, by the testes. This may result in suppressed total serum testosterone to the levels observed in castration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C96432" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C96432" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000698431

Capesaris

GTx-758

C3272775

C3272776

2011-04-04

2011-05-02

An orally available, nonsteroidal selective estrogen receptor (ER) alpha agonist with potential antineoplastic activity. Upon administration of GTx-758, this agent suppresses the secretion of the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the pituitary gland through feedback inhibition. In males, the inhibition of LH secretion prevents the synthesis of androgens, including testosterone, by the testes. This may result in suppressed total serum testosterone to the levels observed in castration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C96432" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C96432" NCI Thesaurus)

TRD

C96432

CDR0000698431

Drug/agent

estrogen receptor agonist GTx-758

T116

T121