Link to this page
Physician Data Query
Id | http://purl.bioontology.org/ontology/PDQ/CDR0000038352
http://purl.bioontology.org/ontology/PDQ/CDR0000038352
|
---|---|
Preferred Name | gastrin immunotoxin |
Definitions |
An immunotoxin containing an epitope of human gastrin conjugated to diphtheria toxin, with antineoplastic activity. The gastrin epitope in this vaccine is chemically identical or similar to the endogenous gastrin-17 (G-17), a 17-amino acid peptide hormone that stimulates secretion of gastric acid by the stomach. Diphtheria toxin inhibits protein synthesis via modifying translation elongation factor 2 (EF-2). Vaccination with this immunotoxin may elicit production of antibodies against gastrinoma cells overexpressing gastrin, in addition to the toxic effects on protein synthesis exerted by the diphtheria toxin moiety. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1692" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1692" NCI Thesaurus)
|
Synonyms |
PAS
G17DT immunogen
Gastrimmune
neutralizing G17 hormone
Insegia
G17DT
G17-DT
anti-gastrin therapeutic vaccine
anti-gastrin 17
neutralize hormone G17
|
Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | An immunotoxin containing an epitope of human gastrin conjugated to diphtheria toxin, with antineoplastic activity. The gastrin epitope in this vaccine is chemically identical or similar to the endogenous gastrin-17 (G-17), a 17-amino acid peptide hormone that stimulates secretion of gastric acid by the stomach. Diphtheria toxin inhibits protein synthesis via modifying translation elongation factor 2 (EF-2). Vaccination with this immunotoxin may elicit production of antibodies against gastrinoma cells overexpressing gastrin, in addition to the toxic effects on protein synthesis exerted by the diphtheria toxin moiety. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1692" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1692" NCI Thesaurus) |
---|---|
altLabel |
PAS
G17DT immunogen
Gastrimmune
neutralizing G17 hormone
Insegia
G17DT
G17-DT
anti-gastrin therapeutic vaccine
anti-gastrin 17
neutralize hormone G17
See more
See less
|
prefLabel | gastrin immunotoxin
|
notation | CDR0000038352
|
ORIG STY | Drug/agent
|
Component of | |
Legacy PDQ ID | 10970
|
Date last modified | 2015-10-06
|
Semantic type UMLS property | |
NCI ID | C1692
|
type | |
LT | TRD
|
tui |
T116
T129
T121
|
cui |
C1619625
C0935889
C4732937
|
Delete | Subject | Author | Type | Created |
---|---|---|---|---|
No notes to display |
- Problem retrieving properties:
Notes
Add NCBO Web Widgets to your site for PDQ
Widget type | Widget demonstration |
---|---|
|
Step 2: Follow the Instructions
For more help visit NCBO Widget Wiki |
|
Example 1 (start typing the class name to get its full URI)
Example 2 (get the ID for a class) Example 3 (get the preferred name for a class) Step 2: Follow the Instructions
For more help visit NCBO Widget Wiki |
|
Step 2: Follow the InstructionsCopy the code below and paste it to your HTML page <iframe frameborder="0" src="/widgets/visualization?ontology=PDQ&class=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FPDQ%2FCDR0000698431&apikey=YOUR_API_KEY"></iframe> For more help visit NCBO Widget Wiki |
|
Step 2: Follow the InstructionsCopy the code below and paste it to your HTML page <link rel="stylesheet" type="text/css" href="/widgets/jquery.ncbo.tree.css"> <script src="/widgets/jquery.ncbo.tree-2.0.2.js"></script> <div id="widget_tree"></div> var widget_tree = $("#widget_tree").NCBOTree({ apikey: "YOUR_API_KEY", ontology: "PDQ" }); You can also view a detailed demonstration For more help visit NCBO Widget Wiki |