Physician Data Query

Last uploaded: August 27, 2019
Id http://purl.bioontology.org/ontology/PDQ/CDR0000038352
http://purl.bioontology.org/ontology/PDQ/CDR0000038352
Preferred Name

gastrin immunotoxin

Definitions
An immunotoxin containing an epitope of human gastrin conjugated to diphtheria toxin, with antineoplastic activity. The gastrin epitope in this vaccine is chemically identical or similar to the endogenous gastrin-17 (G-17), a 17-amino acid peptide hormone that stimulates secretion of gastric acid by the stomach. Diphtheria toxin inhibits protein synthesis via modifying translation elongation factor 2 (EF-2). Vaccination with this immunotoxin may elicit production of antibodies against gastrinoma cells overexpressing gastrin, in addition to the toxic effects on protein synthesis exerted by the diphtheria toxin moiety. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1692" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1692" NCI Thesaurus)
Synonyms
PAS
G17DT immunogen
Gastrimmune
neutralizing G17 hormone
Insegia
G17DT
G17-DT
anti-gastrin therapeutic vaccine
anti-gastrin 17
neutralize hormone G17
Type http://www.w3.org/2002/07/owl#Class
Delete Subject Author Type Created
No notes to display
  • Problem retrieving properties:

Notes

Filter:
Add NCBO Web Widgets to your site for PDQ
Widget type Widget demonstration
Jump To

Type a class name from PDQ and jump to it in BioPortal

Get code
Form Autocomplete

Fill your form fields with classes from PDQ

Get code
Example 1 (start typing the class name to get its full URI)

Example 2 (get the ID for a class)

Example 3 (get the preferred name for a class)
Visualization

Display a visualization for a given class in PDQ

Get code
Tree Widget

Display a class tree with a search field for PDQ

Get code