Physician Data Query

Last uploaded: August 27, 2019
Id http://purl.bioontology.org/ontology/PDQ/CDR0000039224
http://purl.bioontology.org/ontology/PDQ/CDR0000039224
Preferred Name

diazooxonorleucine

Definitions
An L-glutamine diazo analogue amino acid antibiotic isolated from a species of the bacterial genus Streptomyces with potential antineoplastic activity. Diazooxonorleucine inhibits several glutamine-dependent biosynthetic pathways involved in the the syntheses of D-glucosamine phosphate, purines and pyrimidines. This agent inhibits phosphate-activated glutaminase, a key enzyme for the synthesis of releasable glutamine, depleting cells of this essential amino acid and reducing their capacity to proliferate. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C427" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C427" NCI Thesaurus)
Synonyms
6-diazo-5-oxo-L-norleucine
DON
Type http://www.w3.org/2002/07/owl#Class
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