Physician Data Query

Last uploaded: August 27, 2019
Id http://purl.bioontology.org/ontology/PDQ/CDR0000039484
http://purl.bioontology.org/ontology/PDQ/CDR0000039484
Preferred Name

isoniazid

Definitions
A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C600" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C600" NCI Thesaurus)
Synonyms
isonicotinic acid hydrazide
INH
isonicotinyl hydrazine
Type http://www.w3.org/2002/07/owl#Class
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