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Physician Data Query
Id | http://purl.bioontology.org/ontology/PDQ/CDR0000041213
http://purl.bioontology.org/ontology/PDQ/CDR0000041213
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Preferred Name | gemcitabine hydrochloride |
Definitions |
The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C961" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C961" NCI Thesaurus)
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Synonyms |
2'-deoxy-2',2'-difluorocytidine hydrochloride
2'deoxy-2',2'-difluorocytidine hydrochloride
LY-188011
dFdCyd
Gemzar
difluorodeoxycytidine hydrochloride
1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose hydrochloride
LY188011
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C961" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C961" NCI Thesaurus) |
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altLabel |
2'-deoxy-2',2'-difluorocytidine hydrochloride
2'deoxy-2',2'-difluorocytidine hydrochloride
LY-188011
dFdCyd
Gemzar
difluorodeoxycytidine hydrochloride
1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose hydrochloride
LY188011
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prefLabel | gemcitabine hydrochloride
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CAS Registry | 122111-03-9
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notation | CDR0000041213
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NSC Code | 613327
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ORIG STY | Drug/agent
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Component of |
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Legacy PDQ ID | 4286
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Date last modified | 2017-11-28
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Semantic type UMLS property | |
NCI ID | C961
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type | |
LT | TRD
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tui |
T114
T121
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cui |
C0338133
C0701235
C0771488
C0045093
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