Physician Data Query

Last uploaded: August 27, 2019
Id http://purl.bioontology.org/ontology/PDQ/CDR0000041213
http://purl.bioontology.org/ontology/PDQ/CDR0000041213
Preferred Name

gemcitabine hydrochloride

Definitions
The hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C961" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C961" NCI Thesaurus)
Synonyms
2'-deoxy-2',2'-difluorocytidine hydrochloride
2'deoxy-2',2'-difluorocytidine hydrochloride
LY-188011
dFdCyd
Gemzar
difluorodeoxycytidine hydrochloride
1-(2-oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose hydrochloride
LY188011
Type http://www.w3.org/2002/07/owl#Class
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