Physician Data Query

Last uploaded: August 27, 2019
Id http://purl.bioontology.org/ontology/PDQ/CDR0000041719
http://purl.bioontology.org/ontology/PDQ/CDR0000041719
Preferred Name

methotrexate

Definitions
An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C642" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C642" NCI Thesaurus)
Synonyms
Emtexate
Ledertrexate
Rheumatrex
Metex
Tremetex
Lantarel
Metotrexato
Brimexate
Novatrex
amethopterin
4-amino-4-deoxy-10-methylpteroyl-L-glutamic acid
Trexall
MTX
Methoblastin
Emthexate
Lumexon
methotrexate methylaminopterin
Trixilem
4-amino-10-methylfolic acid
methylaminopterin
Maxtrex
Metrotex
CL-14377
Emthexat
Farmitrexat
Fauldexato
WR-19039
Texate
Trexeron
Methotrexatum
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
alpha-methopterin
Medsatrexate
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Type http://www.w3.org/2002/07/owl#Class
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