Physician Data Query

Last uploaded: August 27, 2019
Id http://purl.bioontology.org/ontology/PDQ/CDR0000042033
http://purl.bioontology.org/ontology/PDQ/CDR0000042033
Preferred Name

alteplase

Definitions
A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C39607" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C39607" NCI Thesaurus)
Synonyms
Activase
t-PA
recombinant tissue plasminogen activator
rt-PA
Type http://www.w3.org/2002/07/owl#Class
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