Physician Data Query

Last uploaded: August 27, 2019
Id http://purl.bioontology.org/ontology/PDQ/CDR0000470233
http://purl.bioontology.org/ontology/PDQ/CDR0000470233
Preferred Name

therapeutic triiodothyronine

Definitions
A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C907" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C907" NCI Thesaurus)
Synonyms
Therapeutic T3
L-Triiodothyronine
Triiodothyronine
Liothyronine
Type http://www.w3.org/2002/07/owl#Class
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