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Physician Data Query
Id | http://purl.bioontology.org/ontology/PDQ/CDR0000486330
http://purl.bioontology.org/ontology/PDQ/CDR0000486330
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Preferred Name | coxsackievirus A21 |
Definitions |
A naturally occurring enterovirus with potential antitumor activity. Upon intratumoral administration, coxsackievirus A21 targets and binds to intracellular adhesion molecule 1 (ICAM-1) and decay acceleration factor (DAF), both cell surface molecules that are both overexpressed on certain malignant cells. After entering the cells, coxsackievirus A21 replicates in these cancer cells, thereby causing cancer cell lysis. This results in a reduction of tumor cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61493" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61493" NCI Thesaurus)
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Synonyms |
CAVATAKâ„¢
CVA21
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | A naturally occurring enterovirus with potential antitumor activity. Upon intratumoral administration, coxsackievirus A21 targets and binds to intracellular adhesion molecule 1 (ICAM-1) and decay acceleration factor (DAF), both cell surface molecules that are both overexpressed on certain malignant cells. After entering the cells, coxsackievirus A21 replicates in these cancer cells, thereby causing cancer cell lysis. This results in a reduction of tumor cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61493" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C61493" NCI Thesaurus) |
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altLabel |
CAVATAKâ„¢
CVA21
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prefLabel | coxsackievirus A21
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notation | CDR0000486330
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ORIG STY | Drug/agent
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Date last modified | 2014-01-27
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Semantic type UMLS property | |
NCI ID | C61493
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type | |
LT | TRD
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tui |
T005
T121
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DATE FIRST PUBLISHED | 2006-05-19
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cui |
C1440507
C4732972
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