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Physician Data Query
Id | http://purl.bioontology.org/ontology/PDQ/CDR0000752236
http://purl.bioontology.org/ontology/PDQ/CDR0000752236
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Preferred Name | isoflurane |
Definitions |
A fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake and it may potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65978" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65978" NCI Thesaurus)
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Synonyms |
Aerrane
1-chloro-2,2,2-trifluoroethyl difluoromethyl ether (SN); 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
Forane
Isoflo
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Type | http://www.w3.org/2002/07/owl#Class |
All Properties
definition | A fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake and it may potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65978" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C65978" NCI Thesaurus) |
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altLabel |
Aerrane
1-chloro-2,2,2-trifluoroethyl difluoromethyl ether (SN); 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane
Forane
Isoflo
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prefLabel |
isoflurane
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CAS Registry |
26675-46-7
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notation |
CDR0000752236
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ORIG STY |
Drug/agent
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Date last modified |
2013-09-05
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Semantic type UMLS property | |
NCI ID |
C65978
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type | |
LT |
TRD
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tui |
T109
T121
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DATE FIRST PUBLISHED |
2013-09-05
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cui |
C3651895
C0308273
C0306242
C0022180
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